Highly efficient one pot synthesis of benzimidazoles from 2-nitroaniline and PhSiH3 as reducing agent catalyzed by Pd/C as a heterogeneous catalyst was written by Phatake, Vishal V.;Bhanage, Bhalchandra M.. And the article was included in Tetrahedron Letters in 2021.Electric Literature of C8H8N2 This article mentions the following:
This work reported an efficient route for the synthesis of benzimidazole from o-nitroaniline in the presence of carbon dioxide atm., PhSiH3 as a reducing agent catalyzed by Pd/C as a catalyst. The more efficient route for the synthesis benzimidazole was developed and various substituted benzimidazoles were synthesized in good to excellent yield. The TBD (1,5,7-Triazabicyclo [4.4.0] dec-5-ene) was selected as a base as it promoted the CO2 insertion. Benzimidazoles were synthesized through reduction of nitro group followed by cyclization of amine using CO2 as a carbon source. Moreover, the Pd/C catalyst was recycled upto five recycle run without significant changes in the yield of the product. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem