Effect of some imidazole derivatives on adenosine 3′,5′-monophosphoric acid phosphodiesterase activity was written by Lunts, V. Ya.. And the article was included in Byulleten Eksperimental’noi Biologii i Meditsiny in 1976.Recommanded Product: 3034-41-1 This article mentions the following:
The effect of 24 imidazole derivatives on the activity of phosphodiesterase EC 3.1.4.1. [9025-82-5] was studied in experiments with homogenates of rat brain and of Rana temporaria skeletal muscle. Imidazole [288-32-4] derivatives produced both activating and inhibitory influences on the enzyme. Imidazole and 7 of its alkyl substituted derivatives activated the phosphodiesterase. Tetrachloro-2-trifluoromethylbenzimidazole [2338-29-6] produced the greatest effect among the inhibitors on the phosphodiesterase activity. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 3034-41-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem