Imidazole analogues of resveratrol: synthesis and cancer cell growth evaluation was written by Bellina, Fabio;Guazzelli, Nicola;Lessi, Marco;Manzini, Chiara. And the article was included in Tetrahedron in 2015.SDS of cas: 25676-75-9 This article mentions the following:
Novel trans-restricted analogs of resveratrol in which the C-C double bond of the natural derivative was replaced by diaryl substituted imidazole analogs were designed. The syntheses of 1,4-, 2,4-, and 2,5-diarylimidazoles, in which the two aryl moieties are linked to the heteroaromatic core in a 1,3 fashion to preserve the trans stereochem., were successfully carried out by regioselective sequential transition metal-catalyzed arylations of simple, com. available imidazole precursors. The anticancer activity of selected analogs was evaluated in vitro against the NCI-60 human tumor cell lines panel. From this screening, the authors were able to select a synthetic candidate that resulted more active than its natural lead. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9SDS of cas: 25676-75-9).
4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 25676-75-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem