Aqueous-phase, palladium-catalyzed Suzuki reactions under mild conditions was written by Cai, Yueqin;Song, Gonghua;Wu, Zhongyuan;Zhang, Jiawei. And the article was included in Green and Sustainable Chemistry in 2013.Electric Literature of C11H20N2 This article mentions the following:
A series of biaryls I [R1 = H, 4-Me, 2-MeO, etc.; R2 = H, 4-Me, 4-MeO, etc.] were prepared by Suzuki coupling of aryl halides and aryl boronic acids using ionic liquid-supported diols as phosphine-free ligands under mild conditions in aqueous solvent. It was found that 2,2-bis((1-hexylimidazolium)-methyl) propane-1,3-diol hexafluorophosphate in combination with palladium (II) salts gave the most significant and reusable catalyst. Notably, the reactions of hydrophilic aryl bromides gave high yields in neat water. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).
1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C11H20N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem