Activity of antitumor drugs against african trypanosomes was written by Kinnamon, Kenneth E.;Steck, Edgar A.;Rane, Dora S.. And the article was included in Antimicrobial Agents and Chemotherapy in 1979.Recommanded Product: 26832-08-6 This article mentions the following:
Of 49 compounds with antitumor properties, 6 had significant activity against Trypanosoma rhodesiense infections in mice. In order of decreasing activity these compounds were imidazole-4-carboxamide (I) [26832-08-6], inosine diglycoaldehyde (II) [23590-99-0], cis-diamminedichloroplatinum [15663-27-1], streptozotocin [18883-66-4], coralyne sulfate [38989-37-6], and 5-fluoro-2′-deoxyuridine [50-91-9]. Of these compounds, only diamminedichloroplatinum was toxic. These compounds may have therapeutic importance against Trypanosoma infections. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 26832-08-6).
1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 26832-08-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem