Montanari, F. et al. published their research in Bollettino Scientifico della Facolta di Chimica Industriale di Bologna in 1953 | CAS: 83741-35-9

4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 83741-35-9

Benzimidazoles. III was written by Montanari, F.;Passerini, R.. And the article was included in Bollettino Scientifico della Facolta di Chimica Industriale di Bologna in 1953.Application of 83741-35-9 This article mentions the following:

2,3-(O2N)2C6H3Cl (2 g., 1 equivalent) reduced with 13.5 g. (6 equivalents) SnCl2.2H2O and 15 mL. concentrated HCl, and the product vacuum-distilled (113°/4 mm.) gives 2,3-(H2N)2C6H3Cl (I). Refluxing 1 equivalent I.2HCl 3 h. with 2 equivalents anhydrous HCO2Na gives 4-chlorobenzimidazole, m. 170-1°. 2,3-(H2N)2C6H3Br gives 4-bromobenzimidazole, m. 168°. 2,3-(H2N)2C6H3OMe, m. 39-40°, gives 4-methoxybenzimidazole, m. 168°. 5-Nitro benzimidazole with SnCl2 gives the 5-amino compound, m. 164°. 2-Nitro-6-methylbenzimidazole (15 g.) suspended in 33 mL. concentrated HCl and a little EtOH with 0.21 g. Sn yields the chlorostannate which gives 4-methyl-2-phenylbenzimidazole, m. 246°. BzH with 2,3-(H2N)2C6H3R gives the following 4-R derivatives of 2-phenylbenzimidazole: Cl, m. 227-8°; MeO, m. 214-15°; O2N, m. 194-5°. With 3,4-(H2N)2C6H3OMe, BzH gives 5-methoxy-2-phenylbenzimidazole, m. 218-19°. By reduction of 2-nitro-2′-methylbenzanilide (from ο-nitroaniline and ο-MeC6H4COCl) is obtained 2-ο-tolylbenzimidazole, m. 111-12°. Likewise from the corresponding benzanilides are obtained the following benzimidazoles: 2-m-tolyl, m. 112-13°; 2-(ο-methoxyphenyl), m. 179-80°; and 2-(m-methoxyphenyl), m. 205°. 18 references In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Application of 83741-35-9).

4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 83741-35-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem