DNA-based asymmetric catalysis: role of ionic solvents and glymes was written by Zhao, Hua;Shen, Kai. And the article was included in RSC Advances in 2014.Recommanded Product: 85692-37-1 This article mentions the following:
Stereoselective Michael addition reactions were performed between imidazolylphenylpropenones and di-Me malonate using DNA-based hybrid metal catalyst in ionic liquids, inorganic salts, DES, glymes and glycols as co-solvents (or additives). The unique chiral structure of DNA allowed the hybrid catalysts to catalyze various asym. synthesis reactions. In general, these additives induced indistinguishable changes to the DNA B-form duplex conformation as suggested by CD (CD) spectroscopy, but imposed a significant influence on the catalytic efficiency of the DNA-based hybrid catalyst. Most ILs and inorganic salts caused the deactivation of the hybrid catalyst except 0.2 M [BMIM][CF3COO] (95.4% ee and 93% yield) and 0.2 M [BMIM]Cl (93.7% ee and 89% yield). Several other additives were found to improve the catalytic efficiency of the DNA-based hybrid catalyst (control reaction without additive gives >99% ee and 87% yield), 0.4 M glycerol (>99% ee and 96% yield at 5 °C or 96.2% ee and 83% yield at room temperature), 0.2 M choline chloride-glycerol (1 : 2) (92.4% ee and 90% yield at 5 °C or 94.0% ee and 88% yield at room temperature), and 0.5 M dipropylene glycol di-Me ether (>99% ee and 87% yield at room temperature). A brief pre-sonication (5 min) of DNA in MOPS buffer prior to the reaction improved the performance of the DNA-based hybrid catalyst. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Recommanded Product: 85692-37-1).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 85692-37-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem