Gas-Phase Studies of Substrates for the DNA Mismatch Repair Enzyme MutY was written by Michelson, Anna Zhachkina;Rozenberg, Aleksandr;Tian, Yuan;Sun, Xuejun;Davis, Julianne;Francis, Anthony W.;O’Shea, Valerie L.;Halasyam, Mohan;Manlove, Amelia H.;David, Sheila S.;Lee, Jeehiun K.. And the article was included in Journal of the American Chemical Society in 2012.Application In Synthesis of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:
The gas-phase thermochem. properties (tautomeric energies, acidity, and proton affinity) have been measured and calculated for adenine and six adenine analogs that were designed to test features of the catalytic mechanism used by the adenine glycosylase MutY. The gas-phase intrinsic properties are correlated to possible excision mechanisms and MutY excision rates to gain insight into the MutY mechanism. The data support a mechanism involving protonation at N7 and hydrogen bonding to N3 of adenine. We also explored the acid-catalyzed (non-enzymic) depurination of these substrates, which appears to follow a different mechanism than that employed by MutY, which we elucidate using calculations In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Application In Synthesis of 7-Methyl-1H-benzo[d]imidazole).
7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application In Synthesis of 7-Methyl-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem