Quaternization of azido-N-heteroarenes with Meerwein reagent: A straightforward synthesis of 2-azido(benzo)imidazolium and related azido-N-heteroarenium tetrafluoroborates was written by Li, Yan;Wan, Ting-Biao;Guo, Bin;Qi, Xiao-Wen;Zhu, Chifan;Shen, Mei-Hua;Xu, Hua-Dong. And the article was included in Tetrahedron Letters in 2022.Category: imidazoles-derivatives This article mentions the following:
The 2-azido(benzo)imidazolium salts e.g., I have been made through quaternization of 2-Azido(benzo)imidazoles e.g., II with Meerwein reagent at ambient conditions. This one-pot protocol is also applicable to 4 or 3-azidopyridines e.g., III and appropriate azido(iso)quinolines e.g., IV to prepare correlative azido-N-heteroarenium salts e.g., I. When compared with their precursors, improved diazotransfer reactivity was observed for several representative azido-N-heteroarenium salts e.g., I in reaction with di-Et malonate. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem