Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Example-19: Preparation of Nilotinib : In 3 lit four necked round bottom flask equipped with mechanical stirrer, thermometer, reflux condenser and an addition funnel, 4-methyl-3-{[4-(3-pyridinyl)-2- pyrimidinyl] amino (benzoic acid (100 g) and N-methyl-2-pyrrolidone (750 ml) was added under nitrogen atmosphere at 25-35C and heated to 60-65C. To this, thionylchloride (30 ml) was added at 60-65C and stirred for 3 hrs at the same temperature. After completion of reaction, a solution of 3 -(4-methyl- lH-imidazol-1- yl)-5-(trifluoromethyl)aniline (86.6 g) in N-methyl-2-pyrrolidone (150 ml) was added to the reaction mass at 60-65C over a period of 45 mins. The reaction mass was further heated to 90-95 C and stirred for 5 hrs at the same temperature. After completion of reaction, the reaction mass was cooled to 75-85C and water (1000 ml) was added to it over a period of 60 mins. Then reaction mass basified with aqueous sodium hydroxide solution at 75-85C; cooled to 35-45C and then stirred for 2 hrs. The reaction mass was further cooled to 5-l0C and stirred for 3 hrs. The solid obtained was filtered, washed with water and dried under vacuum for 12 hrs at 60- 65C to get the title compound. Yield: 145 g.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 641571-11-1.
Reference:
Patent; LAURUS LABS LTD; BOLLU, Ravindra Babu; BANDLAMUDI, Veera Narayana; KUDIRILLA, Vivek Kumar; VEMULA, Rambabu; VASIREDDI, Uma Maheswer Rao; (36 pag.)WO2019/130254; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem