The important role of 46006-36-4

The synthetic route of 46006-36-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 46006-36-4, name is 1H-Benzimidazole-7-carboxylic acid, A new synthetic method of this compound is introduced below., Computed Properties of C8H6N2O2

Example 180N-((ls,4s)-4-(5-Fluoro-2-(4′-((4-(2-hydroxyethyl)-l,4-diazepan-l-yl)methyl)-2′-(((S)-3- methylmorpholinoJmethylJbiphenyl-S-yloxyJnicotinamidoJcyclohexylJ-lH- benzo [d] imidazole-4-carboxamide To a solution of N-((ls,4s)-4-aminocyclohexyl)-5-fluoro-2-(4′-((4-(2-hydroxyethyl)-l,4- diazepan- 1 -yl)methyl)-2′-(((S)-3 -methylmorpholino)methyl)biphenyl-3 -yloxy Nicotinamide (200 mg, 0.24 mmol) in dry DMF (5 mL) under nitrogen was added DIPEA (0.161 mL, 0.97 mmol) at RT. The solution was stirred until homogeneous. To this solution was added dropwise a solution of lH-benzo[d]imidazole-4-carboxylic acid (39.5 mg, 0.24 mmol) and l,l’-carbonyldiimidazole (39.5 mg, 0.24 mmol) in dry DMF (5 mL) under nitrogen which had been allowed to stir at 40 0C for 1 hour. The reaction mixture was allowed to stir at 50 0C overnight. The mixture was evaporated to dryness and the residue dissolved in DCM (100 ml) and washed with saturated NaHCC^aq), brine, dried (MgSC^) and evaporated to give a yellow oil. The crude product was purified by preparative HPLC using a 95-5% gradient of aqueous 0.2% ammonia in methanol as eluent to give the the title compound as a white solid. Yield: 22 mg1H NMR (W MHz, CDCl3) delta 8.12 – 8.06 (m, 2H), 7.94 – 7.82 (m, 2H), 7.70 (d, J= 7.9 Hz, IH), 7.43 (d, J= 7.9 Hz, IH), 7.38 – 7.31 (m, 2H), 7.24 – 7.10 (m, 5H), 7.07 (d, J= 7.9 Hz, IH), 4.25 – 4.18 (m, IH), 4.16 – 4.09 (m, IH), 3.82 (d, J= 13.9 Hz, IH), 3.64 – 3.58 (m, 5H), 3.49 – 3.43 (m, IH), 3.40 – 3.31 (m, IH) 3.03 – 2.93 (m, 2H), 2.81 – 2.73 (m, 5H) 2.72 – 2.62 (m, 7H), 2.39 – 2.31 (m, IH), 2.12 – 2.03 (m, IH), 1.98 – 1.74 (m, 10H), 0.66 (d, J= 6.2 Hz, 3H). MS: [M+H]+=819 (calc=819) (MultiMode+)

The synthetic route of 46006-36-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem