These common heterocyclic compound, 40644-16-4, name is 4-Bromo-1H-benzo[d]imidazol-2(3H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H5BrN2O
Step 3: To a solution of 4-bromo-1 ,3-dihydro-benzoimidazol-2-one (701 mg, 3.29 mmol) in DMSO (2 ml.) was added potassium acetate (803 g, 10.9 mmol), 1 ,1 ‘-bis(diphenyl phosphino)ferrocene palladium chloride (134 mg, 0.16 mmol) and bis(pinacolato)diboron (1.67 g, 6.58 mmol), and the reaction was degassed and heated in a microwave reactor for 30 minutes at 150 C. The reaction mixture was then filtered through a pad of Celite, water (60 ml.) was added, and the mixture was extracted with ethyl acetate (3 x 30 ml_). The combined organic extracts were dried over sodium sulfate, filtered, and then concentrated in- vacuo to give 4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-1 ,3-dihydro-benzoimidazol-2- one, which was used in the next step without further purification.
The synthetic route of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; WYETH; WO2009/108838; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem