Adding a certain compound to certain chemical reactions, such as: 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17325-26-7, Application In Synthesis of Methyl 1H-imidazole-5-carboxylate
Methyl 4-imidazolecarboxylate (1.09 g, 8.62 mmol) was slowly added to a suspension of sodium hydride (60% dispersion in oil, 0.52 g, 13 mmol) in DMF (40 mL). The mixture was heated to 80 C. and stirred at this temperature for 1 hour. A solution of compound 8 (3.61 g, 12.90 mmol) in DMF (20 mL) was added dropwise to the reaction mixture at this temperature and the reaction mixture stirred a further 12 hours at 80 C. The cooled mixture was filtered, the volatiles removed in vacuo and the residue purified by column chromatography on silica gel (100% n-heptane to 100% EtOAc) to yield compound 10 (0.91 g, 34%) as a yellow semi solid first LC-MS (MH+): m/z=311.3, tR (min,)=1.15 then compound 9 (1.38 g, yield: 51%) as a yellow solid LC-MS (MH+): m/z=311.3, tR (minutes)=1.16.
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Reference:
Patent; H. Lundbeck A/S; US2012/129836; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem