137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 137049-00-4
To a solution of intermediate 2.40 (20. mg, 0.078 mmol) and triethylamine (30 muL, 0.2 mmol) in dichloromethane (0.5 mL) at ambient temperature was added 1-methyl- 1H-imidazole-4-sulfonyl chloride (21 mg, 0.12 mmol). The resulting mixture was stirred for 18 h, then diluted with wet dimethyl sulfoxide (0.5 mL), filtered through Celite and purified via mass-directed isolation using ultra-performance liquid chromatography (21 mg, 68% yield).1H NMR (500 MHz, Acetonitrile-d3) d 8.64 (s, 1H), 7.70 (dd, J = 11.8, 2.4 Hz, 1H), 7.62 (d, J = 1.4 Hz, 1H), 7.54 (d, J = 1.4 Hz, 1H), 7.37 (t, J = 8.6 Hz, 1H), 7.22 (ddd, J = 8.8, 2.4, 1.2 Hz, 1H), 3.80 (ddd, J = 11.7, 3.7, 1.9 Hz, 1H), 3.71 (s, 3H), 3.63 (d, J = 12.1 Hz, 1H), 2.65 (t, J = 11.1 Hz, 1H), 2.58 (ddt, J = 10.8, 7.2, 3.5 Hz, 1H), 2.52 (td, J = 11.9, 3.0 Hz, 1H), 1.93- 1.89 (m, 1H), 1.85- 1.74 (m, 1H), 1.65- 1.52 (m, 1H), 1.52- 1.39 (m, 1H); AMM (ESI) m/z 401.0858 [calc for C16H19ClFN4O3S (M+H)+ 401.0850].
The synthetic route of 137049-00-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; VAL-CHUM, LIMITED PARTNERSHIP; GRENIER, Melissa Carey; SMITH, Amos B., III; FINZI, Andres; DING, Shilei; CHAPLEAU, Jean-Philippe; (240 pag.)WO2020/28482; (2020); A1;,
Imidazole – Wikipedia,
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