Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C4H6N2O, 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a document, author is Ek, F, introduce the new discover.
Synthesis of fused tetrazole- and imidazole derivatives via iodocyclization
The possibility to prepare fused tetrazole- and imidazole derivatives by iodocyclization in moderate to excellent yields is demonstrated. In some examples the cyclizations were not following Baldwin’s rules entirely, i.e. exo-selectivity. Nucleophilic substitution of the formed iodides gave different results depending on the hardness of the nucleophile. Thus, elimination of the iodide could be a problem but a substitution reaction with ethyl potassium xanthate and a radical reaction using acrylonitrile were tolerated. In addition, we showed that it is possible to selectively use three iodo substituents individually in one of the fused imidazole derivatives. (C) 2003 Elsevier Ltd. All rights reserved.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 822-55-9. Formula: C4H6N2O.