Extracurricular laboratory: Synthetic route of 1H-Imidazole

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-32-4.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C3H4N2

Reference Example 2 1.3 g of sodium hydride (60%) was added to 10 ml of tetrahydrofuran, and a solution of 2.0 g of imidazole in 10 ml of tetrahydrofuran was added dropwise to the resulting suspension. After 2 hours of stirring at 0 C., the solution was mixed with 1.86 ml of chloroacetonitrile and stirred at room temperature for 3 hours. To the reaction solution was added water and chloroform, and the organic layer was collected and dried over anhydrous sodium sulfate, followed by evaporation of the solvent. The residue was subjected to alumina column chromatography eluted with dichloromethane-methanol (200:1) to obtain 1.043 g of 1-cyanomethylimidazole. Mass spectrometry value (m/z): 107 (M+ +1) Nuclear magnetic resonance spectrum (CDCl 3, TMS internal standard) delta: 4.95 (2H, s), 7.06 (1H, d), 7.09 (1H, d), 7.57 (1H, s)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-32-4.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US5565479; (1996); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem