Some common heterocyclic compound, 3034-38-6, name is 5-Nitro-1H-imidazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3034-38-6
A solution of NaOH (1.6 g, 40 mmol) in MeOH (10 mL) was added dropwise to a stirred mixture of 4-nitroimidazole (4.5 g, 40 mmol) and MeOH (40 mL) at rt. After stirring (10min), a trace of insoluble material was filtered off, the clear yellow solution was evaporated under reduced pressure and the residue recrystallised from EtOH to give compound 13 (4.2 g, 79%) as yellow crystals. mp>300 C (lit.17, >300 C). 1H NMR (250.1 MHz, DMSO-d6): d 7.14 (s, 1H, CH), 7.75 (s, 1H, CH). 13C NMR (DMSO-d662.9 MHz): d 131.0 (CH), 145.6 (CH), not observed (CNO2). MS (CI) m/z (%) 112 (M-, 100).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3034-38-6, its application will become more common.