Application of 4857-06-1,Some common heterocyclic compound, 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of compound 2 (2-chloro-1H-benzimidazole; 1 g) inMeOH (30 mL), a solution of Br2/MeOH (1.5 mL/15 mL) was addeddrop wise. The resulting suspension was stirred at room temperature for6 h, added H2O (30 mL) and stirring continued at room temperature for18-20 h. The reaction mixture was filtered and the precipitate waswashed thoroughly with cold H2O until the washing was neutral. Thewhite coloured solid was air dried and crystallized from MeOH. Whitesolid, yield (72%); mp 227-228 C; Rf – 0.52 (EtOAc:Hexane:: 3:7); 1HNMR (400 MHz, DMSO-d6) deltappm: 7.95 (s, 2H), 13.79 (br, s, 1H, eNH);13C NMR (100 MHz, DMSO-d6) deltappm: 120.9, 121.5, 138.7, 140.2; HRMSm/z Calcd. for C7H3Br2ClN2 (M+H)+: 308.8430, Found: 308.8434;Anal. Calcd. For C7H3Br2ClN2: C, 27.05; H, 0.95; Br, 51.45; Cl, 11.42; N,9.01% Found: C, 27.07; H, 0.96; Br, 51.48; Cl, 11.44; N, 9.05%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-1H-benzo[d]imidazole, its application will become more common.