Reference of 71759-87-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 71759-87-0 as follows.
To compound 62.la (0.280g, 0.866mmol, 1.Oeq) in 1,4- dioxane (5. 6mL) was added 4-iodo- 1-methyl- 1H-imidazole (0.151 g, 0.693mmo1, 0. 8eq), Cs2CO3 (0.566g, 1.73mmol, 2.Oeq). The reaction mixture was degassed for 10 mm. under argon atmosphere, then Pd2(dba)3 (0.079g, 0. l73mmol, 0. leq) and Xantphos (0. bOg, 0. l73mmol, 0.2eq) were added, again degassed for 5 mm. The reaction was stirred at 110 C for 2h. Upon completion, reaction mixture was cooled to r.t., transferred in water and product was extracted with ethyl acetate. Organic layers were combined, washed with brine, dried over Na2SO4 and concentrated in vacuo to obtain crude product. This was purified by combi flash using 2% MeOH in CH2C12 as eluantto obtain pure 62.1 (0.llOg, 47.50%). MS(ES): m/z 220.48 [M]t
According to the analysis of related databases, 71759-87-0, the application of this compound in the production field has become more and more popular.