In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17325-26-7 as follows. name: Methyl 1H-imidazole-5-carboxylate
Methyl 1H-imidazole-4-carboxylate (96.5 g, 765.1 mmol) was dissolved in 1.8 LIn N,N-dimethylformamide (DMF), then triphenylchloromethane (213.3 g, 765.1 mmol) was added.Finally, triethylamine (85.2 g, 841.6 mmol) was added.After the addition, the nitrogen was replaced three times, and the reaction was carried out at room temperature for about 2 hours.The TLC detects the completion of the reaction and terminates the reaction. Post processing:The reaction system was slowly poured into 6 L of water, stirred and lysed for 1.0 h, filtered, and the filter cake was washed with 500 ml of water.Drying at 50 C for 4 h gave 282.0 g of an off-white solid in a yield of 100.0%.
According to the analysis of related databases, 17325-26-7, the application of this compound in the production field has become more and more popular.