Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50591-22-5, name is 1-Methyl-1H-benzo[d]imidazol-5-ol, A new synthetic method of this compound is introduced below., SDS of cas: 50591-22-5
To a solution of intermediate 1 (250 mg, 772 umol, 1 .0 eq) and lH-Benzimidazol-5-ol, 1 -methyl- (149 mg, 1.0 mmol, 1.3 eq) in THF (lOmL) was added PPh3 (263 mg, 1.0 mmol, 1.30 eq.) and DIAD (203 mg, 1.0 mmol, 1.3 eq). The mixture was stirred at 15 C for 2 hrs. The solvent was removed. The residue was purified by flash column on silica: eluent: gradient from 0% to 50% ethyl acetate/ petroleum ether and second purification eluent: gradient from 0 % to 5% MeOH / DCM and intermediate 80 (240 mg, 61.6%) yield) was obtained as a colorless solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WU, Tongfei; BREHMER, Dirk; BEKE, Lijs; BOECKX, An; DIELS, Gaston Stanislas Marcella; LAWSON, Edward Charles; MEERPOEL, Lieven; PANDE, Vineet; PARADE, Marcus Cornelis Bernardus Catharina; SCHEPENS, Wim Bert Griet; SUN, Weimei; THURING, Johannes Wilhelmus John F.; VIELLEVOYE, Marcel; (186 pag.)WO2018/65365; (2018); A1;,
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