Adding a certain compound to certain chemical reactions, such as: 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29518-68-1, Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)ethanamine
Carbonyldiimidazole (23.4 g; 0.145 mol) was added to a solution of glutaric acid (8 g; 0.06 mol) in anhydrous tetrahydrofuran (500 ml) and stirred for 2 hours. Then benzimidazolyl ethylamine (21.6 g; 0.133 mol) was added to the reaction mixture. The resulting solution was stirred for 3 hours and allowed to stand at room temperature. The residue of the product was separated, washed with water, and dried. The yield was 21 g (82.9%). Rf 0.21 (2). M.p. 170-170.5 C. [M]+419. 1H-NMR (DMSO): delta, m.d.: 1.61-1.76 (m, 2H, CH2), 1.95-2.07 (t, 2H, CH2), 2.9-3.0 (t, 4H, 2CH2), 3.45-3.55 (quint, 4H, 2CH2), 7.06-7.14 (m, 4H, Ar), 7.39-7.54 (m, 4H, Ar), 7.98-8.08 (t, 2H, Ar), 11.6-12.7 (s, 2H, NH). HPLC under condition B: an individual peak at a retention time of 26.6 min.
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Reference:
Patent; OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU “PHARMENTERPRISES”; NEBOLSIN, Vladimir Evgenievich; KROMOVA, Tatyana Alexandrovna; ZHELTUKHINA, Galina Alexandrovna; (19 pag.)US2016/31858; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem