Application of 68468-39-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68468-39-3, name is 5-Bromo-1H-benzo[d]imidazole-2(3H)-thione belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: 2,4-Dinitrochlorobenzene (1 mmol), 2-mercapto-5-substituted benzimidazoles (1 mmol) and Potassium hydroxide (1 mmol) were suspended in aqueous-EtOH (1:1). The reaction mixture was stirred vigorously for about 30 minutes and then refluxed on water bath for 2.5 h, at which point it cleared and TLC analysis indicated complete consumption of the reactants. The reaction mixture was diluted with 50 mL of water and cooled in ice, and the precipitate was collected by filtration. After being washed with cold water (2 x 25 mL), the precipitate was dried under vacuum to afford a pure product (3a-d).
The synthetic route of 5-Bromo-1H-benzo[d]imidazole-2(3H)-thione has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kankala, Shravankumar; Kankala, Ranjith Kumar; Gundepaka, Prasad; Thota, Niranjan; Nerella, Srinivas; Gangula, Mohan Rao; Guguloth, Hanmanthu; Kagga, Mukkanti; Vadde, Ravinder; Vasam, Chandra Sekhar; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1306 – 1309;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem