Synthetic Route of 1008360-84-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1008360-84-6, name is 5-Bromo-6-fluoro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
step 4: A mixture of 100 (550 mg, 2.57 mmol), TsOH-H20 (50 mg, 0.26 mmol), and 3,4-dihydro-2H- pyran (1.08 g, 12.85 mmol) in THF (10 mL) was heated at reflux overnight. After the solvent was removed in vacuo, the residue was partitioned between DCM (300 mL) and water (100 mL). The organic layer was separated, dried (MgSO i), filtered and concentrated in vacuo. The residue was purified by S1O2 chromatography eluting with a MeOH/DCM gradient (0.5 to 1% MeOH) to afford 817 mg (100%) of 5- bromo-6-fluoro-l -(tetrahydro-2H-pyran-2-yl)-lH-benzo[d]imidazole (102) as yellow oil: MS (ESI) m/z = 299 [M+l] +.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-6-fluoro-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim; WO2013/26914; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem