These common heterocyclic compound, 89088-69-7, name is 1-Methyl-1H-imidazol-4-amine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H8ClN3
Intermediate 69; 6-Chloro-iV-( 1 -methyl- lH-imidazol-4-vO- 1 -(tetrahvdro-2H-pyran-2-vO- 1 H-pyrazolo [3 A- dlpyrimidin-4-amineTo a solution of 4,6-dichloro-l-(tetrahydro-2H-pyran-2-yl)-lH-pyrazolo[3,4-d]pyrimidine(Intermediate 70, 3.168 g, 11.60 mmol) in ethanol (60 mL), was added TEA (4.04 mL, 29.00 mmol) followed by 1 -methyl- lH-imidazol-4-amine hydrochloride (Intermediate 36, 1.549 g,11.60 mmol). The resulting mixture was heated at 600C for 2 hours. Evaporation of the volatiles under reduced pressure gave a residue, which was purified utilizing ISCO (EtOAc/hexanes0->80%) to give the title product (1.56g).LCMS: 334 [M+Eta]+.
The synthetic route of 1-Methyl-1H-imidazol-4-amine hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; CHUAQUI, Claudio, Edmundo; HUANG, Shan; IOANNIDIS, Stephanos; SHI, Jie; SU, Mei; SU, Qibin; WO2010/38060; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem