Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., Safety of 1H-Imidazole
The starting material was prepared as follows : 1-Methoxymethyl-imidazole To a solution of imidazole (1. 00 g, 14. 7 MMOL) in anhydrous THF (30 ML) AT-78 C was added in portions sodium hydride (0. 88 g of a 60% dispersion in oil, 22. 0 MMOL). The mixture was avowed to warm to room temperature, stirred for 30 minutes, then cooled to- 78 C, and chloromethyl methyl ether (1. 06 ML, 14. 0 MMOL) SLOWLY added. After 2 hours at- 78 C, sat. NAHC03 was added to quench the reaction. The solvent was removed and a solution of the resultant residue in ethyl acetate was washed with sat. NAHC03, dried over MgS04, filtered, and concentrated to give 1. 3 G OF an oil, which contained the NaH dispersion oil, displayed AN 1H NMR that matched previous (Zhao, et AL., J. Med. CHEM., VOL. 40, pp. 216-225 (1997)), and was used without further purification
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PFIZER INC.; WO2004/74283; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem