60-56-0, Name is 1-Methyl-1H-imidazole-2(3H)-thione, 60-56-0, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
A solution of 0.139 g (1.22 mmol) of imidazole 2 in 2 mL of DMF and 0.084 g (0.66 mmol) of K2CO3 were added to a solution of 0.298 g (1.22 mmol) of thiaselenole 1 in 3 mL of DMF. The reaction mixture was stirred at room temperature for 2 h, diluted with water (50 mL), and the reaction products were extracted with CCl4 (3 ¡Á 5 mL). The extract was washed with water (3 ¡Á 5 mL), dried over Na2SO4, and the solvent was removed in a vacuum. Yield 0.270 g (80%), brown oily substance. 1H NMR spectrum (CDCl3), delta, ppm: 3.08 d.d (1, Se, 2J12.1, 3J 7.8 Hz), 3.43 d.d (1, Se, 2J 12.1, 3J2.6 Hz), 3.57 s (3, N3), 4.80 d.d (1, SS, 3J7.8, 3J 2.6 Hz), 6.24 d (1, =S, 3J 9.9 Hz), 6.34 d(1, SeCH=, 3J 9.9, 2JSe,H 51.2 Hz), 6.89 d (1, 5, 3J1.3 Hz), 6.97 d (1, 4, 3J 1.3 Hz). 13C NMR spectrum(CDCl3), delta, ppm: 24.58 (2Se, 1JC,Se 64.0 Hz), 33.55(N3), 47.27 (SS), 109.61 (=Se, 1JSe,C 116.6 Hz),117.86 (=S), 122.85 (5), 129.49 (4), 137.56 (C2).77Se NMR spectrum (CDCl3), delta, ppm: 193.3. 15N NMRspectrum (CDCl3), delta, ppm: -212.0 (N1), -109.7 (N3).Mass spectrum, m/z (Irel, %): 278 (71) [M]+, 219 (10),197 (16), 164 (57), 151 (15), 139 (100), 114 (95), 84(78), 60 (49), 42 (54). Found, %: C 34.47; H 3.54; N9.92; S 23.00. C8H10N2S2Se. Calculated, %: C 34.65;H 3.64; N 10.10; S 23.13.
Statistics shows that 1-Methyl-1H-imidazole-2(3H)-thione is playing an increasingly important role. we look forward to future research findings about 60-56-0.
Reference:
Article; Amosova; Filippov; Potapov; Makhaeva; Albanov; Russian Journal of Organic Chemistry; vol. 54; 11; (2018); p. 1697 – 1701; Zh. Org. Khim.; vol. 54; 11; (2018); p. 1682 – 1686;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem