Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3034-38-6, name is 5-Nitro-1H-imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H3N3O2
EXAMPLE 2 202 parts of 5-nitroimidazole is dissolved in 600 parts of formic acid (90% by weight), 250 parts of dimethyl sulfate is added and the whole is heated for 6 hours. The formic acid is distilled off in vacuo. 420 parts of water is added to the residue, the whole cooled to from 0 to 5 C. and the unreacted 5-nitroimidazole (60 parts) is centrifuged off. The mixture is adjusted to pH 10 with aqueous ammonia solution (25% by weight) and the precipitate is separated at 0 to 5 C. 130 parts of 1-methyl-5-nitroimidazole having a melting point of 58 to 60 C. is obtained; this is equivalent to a yield of 82% of theory based on reacted 4(5)-nitroimidazole.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BASF Aktiengesellschaft; US4021442; (1977); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem