Application of 15965-54-5, The chemical industry reduces the impact on the environment during synthesis 15965-54-5, name is 2-Chloro-5-methoxy-1H-benzo[d]imidazole, I believe this compound will play a more active role in future production and life.
EXAMPLE 158 5-Methoxy-2-chlorobenzimidazole (0.55 g), thiourea (0.2 g) and ethanol (10 ml) were refluxed for 2 hours. To the reaction mixture was added a solution of 1-methyl-8-chloromethyl-1,2,3,4-tetrahydroquinoline hydrochloride (0.51 g) and sodium hydroxide (0.3 g) in water (5 ml) and the mixture was refluxed for 5 hours. After completion of the reaction, ethanol was distilled off and water was added to the resulting residue, and the mixture was extracted with chloroform. After drying over anhydrous magnesium sulfate, chloroform was distilled off. The resulting residue was purified by silica gel column chromatography [eluent:n-hexane-ethyl acetate (4:1)] to give 8-(5-methoxy-2-benzimidazolyl)thiomethyl-1-methyl-1,2,3,4-tetrahydroquinoline (0.62 g). NMR (CDCl3) delta: 1.60-2.00 (2H, m), 2.70 (2H, t, J=7 Hz), 2.73 (3H, s), 2.83-3.23 (2H, m), 3.73 (3H, s), 4.30 (2H, s), 6.67-7.40 (6H, m), 12.50 (1H, br.).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-methoxy-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Otsuka Pharmaceutical Co., Ltd.; US4963566; (1990); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem