Application of 137049-00-4, These common heterocyclic compound, 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To an 93 (R)-N-methyl-N-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5aa (70.0mg, 0.322mmol) solution in 1.00mL of 119 dichloromethane in a 5mL round-bottom flask, 151 methanesulfonyl chloride (36.9mg, 0.322mmol) and 121 N,N-diisopropylethylamine (0.0590mL, 0.339mmol) were added. Then, the reaction solution was stirred at room temperature overnight before being concentrated under reduced pressure. The residue was purified by flash column chromatography (methanol: dichloromethane=2:98).
The synthetic route of 137049-00-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chough, Chieyeon; Joung, Misuk; Lee, Sunmin; Lee, Jaemin; Kim, Jong Hoon; Kim, B. Moon; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1495 – 1510;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem