Application of 96797-15-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 96797-15-8 as follows.
A. 5-imidazol-4-yl-2-methoxypyridine. To a solution of 4-IODO-1- TRITYL-LH-IMIDAZOLE (25 g, 57.2 mmoles) in THF (150 ml) at room temperature was added ethylmagnesium bromide (69 ml, 68.7 mmoles) under dry conditions. After stirring for 90 minutes, zinc chloride (9.4 g, 68.6 mmoles) was added to the reaction mixture. After stirring for another 90 minutes, tetrakis (triphenylphosphine) palladium (6.6 g, 5.72 mmoles) and 5-BROMO-2-METHOXYPYRIDINE (8.9 ml, 68.7 mmoles) were added to the reaction mixture. Following that, the reaction mixture was heated in a 70C oil bath overnight. Upon cooling, the reaction was diluted with dichloromethane (500 ml) and washed with a 30% NaOH solution containing an added 20 g of EDTA (3x 200 ml), with NACI (sat. ) (200 ml), dried over MGS04, filtered, and concentrated. To the crude material was added dichloromethane (200 ml) and trifluoroactetic acid (40 ml, 410 mmoles). After standing for 6 hours, the reaction was concentrated and pumped on overnight. The crude material was purified by flash chromatography using 0-5% MEOH/CH2CL2 with 0.1% triethylamine yielding 5-imidazol-4-yl-2- methoxypyridine (7. 0g, 70%). MH+ (176)
According to the analysis of related databases, 96797-15-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHIRON CORPORATION; WO2004/96822; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem