Synthetic Route of 360-97-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 360-97-4 name is 4-Amino-1H-imidazole-5-carboxamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 5-amino-1H-imidazole-4-carboxamide (820mg, 6.5mmol), compound 40a (1.83 mg,6.5 mmol), and Et3N (3 mL) in dry acetonitrile (40 mL) was heated at 50 C for 16 h. After cooling,The brown solid precipitated was collected by filtration and washed with H2O to affordcompound 40b (433 mg, 37%) without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-1H-imidazole-5-carboxamide, and friends who are interested can also refer to it.
Reference:
Article; Bai, Gang; Cai, Shi; Chen, Yun; Ding, Jian; Duan, Wenhu; Ning, Yi; Song, Peiran; Xie, Hua; Zhang, Huibin; Zhang, Tao; Zhou, Jinpei; European Journal of Medicinal Chemistry; vol. 190; (2020);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem