Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 705-09-9, name is 2-(Difluoromethyl)-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Computed Properties of C8H6F2N2
the 4 – (4, 6 – dichloro pyrimidine -2 – yl) morpholine (500 mg, 2 . 14mmol), 2 – (difluoromethyl) – 1H – benzo [d] imidazole (720 mg, 4 . 27mmol), NaHCO3 (900 mg, 10 . 7mmol) dissolved in DMF (15 ml) in, replace the nitrogen air 3 times, the mixture in the 110 C stirring for 8 hours, to the reaction solution in the addition of water (50 ml), ethyl acetate extraction, concentration of the organic layer, for purification column chromatography (PE: EA=5:1), a 4 – (4 – chloro -6 – (2 – (difluoromethyl) – 1H – benzo [d] imidazole -1 – yl) pyrimidine -2 – yl) morpholine (200 mg, yield 26%).
The synthetic route of 705-09-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Huilun Life Technology Co., Ltd.; Cheng Jianjun; Qin Jihong; (41 pag.)CN104557871; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem