Application of 39021-62-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39021-62-0 as follows.
COMPOUND 12.1. 51: 4-{6,7-DIMETHOXY-3-METHYL-2-[(4-METHYL-1H- IMIDAZOL-5-YL) METHYL1-l, 2, 3, 4-TETRAHYDROISOQUINOLIN-l-YL}-N*N- DIETHYLBENZAMIDE; Methyl-imidazole-5-carboxyaldehyde (55.9 mg, 0.51 mmol) was added to a solution of INTERMEDIATE 5.1. 14 (97 mg, 0.25 mmol) in 1,2-dichloroethane (4 mL) and the reaction mixture stirred at room temperature for 10 min. Sodium triacetoxyborohydride (378 mg, 1.78 mmol) was added followed by N-methyl-2- pyrrolidinone (320 uL) and the reaction mixture stirred at RT for 22 h. 1 N NaOH (2.5 mL) was added and the organic solvent removed in vacuo. The residue was extracted with DCM (3 x 10 mL) and the organic layer washed with water (10 mL). The organic layer was concentrated in vacuo and the residue purified by repeated flash chromatography on Si02 column (EtOAc: MeOH 95: 5) to afford COMPOUND 12.1. 51 as an oil (85.9 mg, 71%). 1H NMR (500 MHz, CDC13) : 6 1.10 (br s, 3H), 1.24 (br s, 3H), 1.45 (d, J6. 5 Hz, 3H), 2.30 (s, 3H), 3.15-3. 30 (m, 4H), 3.53 (m, 2H), 3.64 (s, 3H), 3.90 (s, 1H), 3.91 (s, 3H), 4. 49 (d, J 14.5 Hz, 1H), 4.62 (d, J 14.5 Hz, 1H), 5.59 (s, 1H), 6.26 (s, 1H), 6.74 (s, 1H), 7.21-7. 31 (m, 4H), 8.24 (s, 1H) ; 13C NMR (125 MHz, CDC13) : 8 9.28, 12.82, 14.11, 19.11, 32.83, 40.13, 43. 83, 46.93, 56.19, 56.25, 59.95, 67.61, 111. 10, 111. 24,119. 36,121. 66,123. 61, 127. 29,129. 60,132. 72, 134.35, 137.08, 137.66, 149.15, 150.07, 170.73 ; (+) LRESIMS m/z 477. 39 [M+H] +.
According to the analysis of related databases, 39021-62-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem