Application of 19225-92-4

The synthetic route of 2-(Chloromethyl)-1-methyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Electric Literature of 19225-92-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19225-92-4, name is 2-(Chloromethyl)-1-methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 50; N-{5-amino-3-cyano-1- [2, 6-dichloro-4-pentafluorothiophenyl]-1 H-pyrazol-4-yl}-N [ (1- methyl-1 H-imidazol-2-yl) methyl] methanesulfonamide; To a mixture of Example 38 (200 mg, 0.42 mmol) and 1- (N-methyl)-2- chloromethylimidazole (106 mg, 0.64 mmol) in acetonitrile (12 ml) was added potassium carbonate (116 mg, 0.84 mmol). The reaction mixture was then stirred at 40C for 18 h. To the reaction mixture was added water (6 mi) and ethyl acetate (10 ml). The two layers were separated and the aqueous layer was extracted with ethyl acetate (2 x 5 ml). The combined organic phases were then dried (MgS04) and concentrated in vacuo. The residue was dissolved in acetonitrile/water (3 mi) and the solution was purified by automated preparative liquid chromatography (Gilson system, 150 x 50 mm, LUNA II C18 10 zm column) using an acetonitrile : water gradient [45: 55 to 95: 5]. The appropriate fractions were concentrated to give the titled compound (98 mg). Experimental MH+ 565.9 ; expected 566.0 ‘H-NMR (CDC13) : 2.88-2. 91 (3H), 3.70-3. 74 (3H), 4.80-5. 03 (2H), 6.09-6. 18 (2H), 6.87-6. 89 (1 H), 6.92-6. 95 (1 H), 7.87-7. 90 (2H)

The synthetic route of 2-(Chloromethyl)-1-methyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/90313; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem