Application of 3724-19-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor. Author is Lu, Shui-Yu; Watts, Paul; Chin, Frederick T.; Hong, Jinsoo; Musachio, John L.; Briard, Emmanuelle; Pike, Victor W..
Carboxylic esters were successfully labeled with one of two short-lived positron-emitters, carbon-11 or fluorine-18, within a hydrodynamically-driven micro-reactor. Non-radioactive Me 3-pyridinepropanoate (I) was obtained at room temperature; its yield increased with higher substrate concentration and with reduced infusion rate. Radioactive I was obtained from the acid (10 mM) and 11CH3I in 56% decay-corrected radiochem. yield (RCY) at an infusion rate of 10 μL min-1, and when the infusion rate was reduced to 1 μL min-1, the RCY increased to 88%. The synthesis of the non-radioactive 2-fluoroethyl ester required heating of the micro-reactor on a heating block at 80 °C (14-17% RCY), while the radioactive ester was obtained in 10% RCY. Radioactive 2-PhOC6H4NAcCH2C6H4CO2Me was obtained from the acid and 11CH3I in 45% RCY at an infusion rate of 10 μL min-1. When the infusion rate was reduced to 1 μL min-1, the RCY increased to 65%. The results exemplify a new methodol. for producing radiotracers for imaging with positron emission tomog. that has many potential advantages, including a requirement for small quantities of substrates, enhanced reaction, rapid reaction optimization and easy product purification
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem