Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Inhibition of Human Neutrophil Elastase with Peptidyl Electrophilic Ketones. 2. Orally Active PG-Val-Pro-Val Pentafluoroethyl Ketones.Product Details of 3724-19-4.
Valylprolylvalyl pentafluoroethyl ketones with different N-protecting groups were evaluated in vitro and in vivo as inhibitors of human neutrophil elastase (HNE). Several of these compounds were found to be orally active in HNE-induced rat and hamster lung hemorrhage models. The morpholinylcarbonylbenzoyl derivative I (MDL 101,146), was studied in greater detail. Hydration and epimerization studies were performed on I and related compounds in various media, including human blood serum. High-performance liquid chromatog. studies on a reversed-phase system as a measure of the lipophilicity of I and related compounds revealed that the orally active compounds fell in a small range of relative retention times. The Ki value determined for I vs HNE was 25 nM.
In some applications, this compound(3724-19-4)Product Details of 3724-19-4 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem