So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Martinez, Roberto; Espitia-Pinzon, Clara I.; Silva Miranda, Mayra; Chavez-Santos, Rosa Maria; Pretelin-Castillo, Gustavo; Ramos-Orea, Aldahir; Hernandez-Baez, Angela M.; Cotlame-Perez, Sandra; Pedraza-Rodriguez, Rogelio researched the compound: Methyl 5-chlorofuran-2-carboxylate( cas:58235-81-7 ).Reference of Methyl 5-chlorofuran-2-carboxylate.They published the article 《Synthesis and antituberculosis activity of new acylthiosemicarbazides designed by structural modification》 about this compound( cas:58235-81-7 ) in Drug Development Research. Keywords: benzamidocarbamothioyl pyridinecarboxamide preparation antituberculosis activity SAR; acylthiosemicarbazides; antituberculosis agents; design; isosteric modification; synthesis. We’ll tell you more about this compound (cas:58235-81-7).
Acylthiosemicarbazides I [R = 5-nitro-1H-pyrrol-2-yl, 4-chlorophenyl, 5-nitrofuran-2-yl, etc.; R1 = 5-chloropyrrol-2-oyl, 4-chlorophenyl, 3,4-dichlorophenyl, etc.] were designed by structural modification of lead N-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)5-nitrofuran-2-carboxamide. The syntheses of I involve a five-step procedure starting from carboxylic acids. Compounds I were tested against three Mycobacterium tuberculosis strains to measure their inhibitory antituberculosis activities. These activities were explained according to the presence or absence of the chlorine substituent in the aromatic ring of the amide joined to the thiosemicarbazide core. Thiosemicarbazide derivative I [R = R1 = phenyl] is a candidate for the development of novel antitubercular agents. Ongoing studies are focused on exploring the mechanism by which these compounds inhibit M. tuberculosis cell growth.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem