Reference of 30148-21-1,Some common heterocyclic compound, 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
IM-1 (1.8 g) was dissolved in concentrated H2S04 (5 mL) and cooled to 0C. Nitric acid (90%, 5 mL) was slowly added and the solution warmed to room temperature and then refluxed at-20C for 1.5 hr. The reaction was quenched by pouring onto ice (50 mL). The resulting blue solution was extracted with DCM, dried over sodium sulphate, and evaporated under vacuum to yield a tanned and oily product. The residue was precipitated with CCL4 : EtOH (1 : 1, 5 mL) to yield the product as white crystals. Yield (1.0543 g, 45%). H NMR (DMSO): 6 8.61 (s, 1H), 4.33 (q, 2H, J=6. 4 Hz), 3.97 (s, 3H), 1.29 (t, 3H, J=6. 0 HZ). 13C (DMSO) : 158.2, 145.4, 135.3, 127.4, 62.2, 37.3, 14.5.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 1-methyl-1H-imidazole-2-carboxylate, its application will become more common.
Reference:
Patent; UNIVERSITY OF WESTERN SYDNEY; WO2005/33077; (2005); A1;,
Imidazole – Wikipedia,
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