Synthetic Route of 401567-00-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 401567-00-8, name is 2-Chloro-1H-benzo[d]imidazole-5-carbonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
4.1.19. 5-Cyano-2-(4-isopropoxyphenoxy)-1-((2-(trimethylsilyl)ethoxy)methyl)benzimidazole and 6-cyano-2-(4-isopropoxyph-enoxy)-1-((2-(trimethylsilyl)ethoxy)methyl)benzimidazole (18) To a solution of 17 (0.60 g, 2.0 mmol) and 4-isopropoxyphenol(0.46 g, 3.0 mmol) in DMF (10 mL) was added Cs2CO3 (1.9 g,5.9 mmol), and the mixture was stirred at room temperatureovernight. The reaction was quenched by addition of water, andthe resulting mixture was extracted with AcOEt. The combinedorganic layer was washed with brine, dried over Na2SO4 and con-centrated under reduced pressure. The residue was puried bysilica gel column chromatography (n-hexane/AcOEt = 3:1) toafford the product 18 (0.83 g, 99%, 1:1 regioisomeric mixture)asa pink oil.1H NMR (500 MHz, CDCl3) d 7.83 (s, 1/2H), 7.68 (d, J = 1.1 Hz,1/2H), 7.59 (d, J = 8.0 Hz, 1/2H), 7.51-7.47 (m, 1H), 7.44 (d,J = 8.0 Hz, 1/2H), 7.26-7.23 (m, 2H), 6.96-6.93 m, 2H), 5.56 (s,1H), 5.56 (s, 1H), 4.56-4.51 (m, 1H), 3.68-3.64 (m, 2H), 1.36 (d J = 6.0 Hz, 6H), 0.99-0.93 (m, 2H), 0.01 to 0.04 (m, 9H); ESI-TOF-HRMS calcd for C23H29N3O3Si (m/z) [M+Na]+ 446.1870, found446.1870.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-1H-benzo[d]imidazole-5-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Okazaki, Shogo; Noguchi-Yachide, Tomomi; Sakai, Taki; Ishikawa, Minoru; Makishima, Makoto; Hashimoto, Yuichi; Yamaguchi, Takao; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5258 – 5269;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem