He, Zhonghan; Li, Yanfeng; Lian, Zhenwei; Liu, Jin; Xian, Hongyi; Jiang, Ran; Hu, Zuqing; Fang, Daokui; Hu, Dalin published the artcile< Exosomal secretion may be a self-protective mechanism of its source cells under environmental stress: A study on human bronchial epithelial cells treated with hydroquinone>, Product Details of C30H30Cl2N6O2, the main research area is bronchial epithelial cell line hydroquinone exosomal secretion environmental stress; DNA damage; exosomal secretion; human bronchial epithelial cells; hydroquinone; toxic effects.
Accumulating evidence reveals that exosome plays an important role in cell-to-cell communication in both physiol. and pathol. processes by transferring bioactive mols. However, the role of exosomal secretion in the adaptation of its source cells to the stimuli of environmental chems. remains elusive. In this study, we revealed that the exposure of hydroquinone (HQ; the main bioactive metabolite of benzene) to human bronchial epithelial cells (16HBE) resulted in decreased ability of cell proliferation and migration, and simultaneously DNA damage and micronuclei formation. Interestingly, when exosomal secretion of HQ treated 16HBE cells was inhibited with the inhibitor GW4869, cellular proliferation and migration were further significantly reduced; concurrently, their DNA damage and micronuclei formation were both further significantly aggravated. Herein, we conclude that exosomal secretion of 16HBE cells may be an important self-protective function against the toxic effects induced by HQ.
Journal of Applied Toxicology published new progress about Cell migration. 6823-69-4 belongs to class imidazoles-derivatives, and the molecular formula is C30H30Cl2N6O2, Product Details of C30H30Cl2N6O2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem