Hu, Miao; Lin, Zidong; Li, Jianxiao; Wu, Wanqing; Jiang, Huanfeng published the artcile< Palladium-catalyzed ionic liquid-accelerated oxidative annulation of acetylenic oximes with unactivated long-chain enols>, Formula: C6H9ClN2O2, the main research area is isoxazole regioselective green preparation; oxime acetylenic enol oxidative annulation alkylation tandem palladium catalyst; allyl alc oxime oxidative annulation allylation tandem palladium catalyst.
A method was developed for the synthesis of isoxazoles such as I [R1 = H, Me, 4-BrC6H4, etc.; R2 = Pr, cyclopentyl, 4-MeC6H4, etc.; R3 = H, Br, n-Pr, etc.; X = CH2, O; n = 1, 2, 3, 4, 5] via palladium-catalyzed ionic liquid-accelerated oxidative cascade annulation/functionalization of acetylenic oximes with unactivated long chain enols/allylic alcs. under aerobic conditions. This newly developed protocol provides the rapid and straightforward synthetic strategy for the assembly of structurally diverse isoxazole architectures under mild conditions with high atom- and step-economy and exceptional functional group tolerance. Notably, the ionic liquid acts as not only a solvent in the reaction but also provided the excess halide ions to eliminate hydrochloride from acetylenic oximes. Moreover, this catalytic system could be recycled up to eight times and reused without significant loss of the catalytic activity.
Green Chemistry published new progress about Alcohols, unsaturated Role: RCT (Reactant), RACT (Reactant or Reagent). 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Formula: C6H9ClN2O2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem