《N-Heterocyclic carbene (NHC)-catalyzed tandem imine umpolung-aza-Michael addition-oxidation of β-carboline cyclic imines》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Satyam, Killari; Harish, Battu; Nanubolu, Jagadeesh Babu; Suresh, Surisetti. Application of 141556-45-8 The article mentions the following:
An NHC-catalyzed umpolung of β-carboline-based cyclic imines for their conversion to the corresponding N-substituted cyclic amides. The key to the success of this transformation appears to be that NHC upon reaction with the imine concomitantly goes through the generation of an aza-Breslow intermediate and aza-Michael addition followed by oxidation with mol. oxygen to deliver the N-substituted amide products. The developed method has enabled the synthesis of various biol. relevant β-carboline-1-one derivatives in good yields. After reading the article, we found that the author used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application of 141556-45-8)
1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application of 141556-45-8
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem