《Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis》 was written by Gao, Guo-Lin; Yang, Chao; Xia, Wujiong. Category: imidazoles-derivativesThis research focused ontrifluoromethyl benzoimidazole preparation; benzimidazole trifluoromethylation photoredox catalyst togni reagent. The article conveys some information:
A new strategy for the preparation of trifluoromethyl benzimidazoles I (R = H, 5,6-di-Me, 5-Cl, etc.; R1 = H, CH3, C6H5CH2, etc.; X = H, CH2OCH3, pyridin-2-yl, etc.) via visible light induced C-H trifluoromethylation at C4 of benzimidazoles II using Togni’s reagent in the presence of fac-Ir(ppy)3 has been presented. Its advantages are operational simplicity, mild reaction conditions, low catalyst loading and wide substrate scope, in which electron-withdrawing, electron-donating groups and different protecting groups are tolerated. After reading the article, we found that the author used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Category: imidazoles-derivatives)
2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem