Boehme, Matthias D.; Wilm, Lukas F. B.; Hepp, Alexander; Hahn, F. Ekkehardt published an article in 2021. The article was titled 《Regioselective Double Oxidative Addition of Bis-NHC Precursors》, and you may find the article in European Journal of Inorganic Chemistry.Category: imidazoles-derivatives The information in the text is summarized as follows:
The 4,4′-dimethylenebiphenyl linked sym. bis-(2-chlorobenzimidazole) (1) and the unsym. 2-chlorobenzimidazolium/2-chlorobenzimidazole [2(BF4)] have been reacted with one equiv of [Pd(PPh3)4] in oxidative addition reactions. For the sym. bis-NHC precursor 1, double metalation of both 2-chlorobenzimidazole sites to give the dinuclear bis-pNHC complex ([3][BF4]2) was observed The unsym. compound 2(BF4) was only metalated at the 2-chlorobenzimidazolium site with formation of the mononuclear NHC complex ([4][BF4]). The remaining 2-chlorobenzimidazole moiety was subsequently metalated in a second oxidative addition reaction with [M(PPh3)4] (M = Pd, Pt) to give the homobimetallic NHC/pNHC complex [5](BF4)2 (M = Pd) and the heterobimetallic complex [6](BF4)2 demonstrating the unique site-selective metalation of the bis-NHC precursor 2(BF4) by two consecutive oxidative additions After reading the article, we found that the author used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Category: imidazoles-derivatives)
2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem