In 2003,Australian Journal of Chemistry included an article by Indusegaram, Sutharsiny; Katsifis, Andrew G.; Ridley, Damon D.; Vonwiller, Simone C.. Formula: C10H12N2O. The article was titled 《Nitrogen versus Oxygen Group Protection in Hydroxypropylbenzimidazoles》. The information in the text is summarized as follows:
In order to convert 1’H-benzimidazol-2′-yl-propanols into aryl ethers using Mitsunobu coupling, it was necessary to protect the benzimidazole nitrogen in the starting alcs. Selective protection at nitrogen was achieved through N-benzyl derivatives, but attempts to protect the nitrogen directly through tert-butoxycarbonyl, acetyl, trityl, or tetrahydropyranyl derivatives were complicated either by selective reactions at oxygen or by the formation of bis-protected compounds Transformations of some oxygen-protected derivatives are discussed, and in particular the conversion of the acetates of 1’H-benzimidazol-2′-yl-propanols to N-tetrahydropyranyl derivatives is described. Mitsunobu coupling involving the N-benzyl and N-tetrahydropyranyl derivatives and Me 4-hydroxybenzoate were achieved, and thus afforded synthetic routes to the desired propylbenzimidazole aryl ethers. The experimental part of the paper was very detailed, including the reaction process of 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9Formula: C10H12N2O)
3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol(cas: 2403-66-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Formula: C10H12N2O However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem