Kochergin, P. M. published the artcile< Imidazole series. XV. Reaction products of N,N'-dimethyloxamide with pentahalo phosphorus compounds>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is .
14660a. Heating 2 kg. PCl5 with 550 g. (CONHMe)2 1-1.5 hrs. at 95-8° (exothermic initially), followed by further 1.6 hrs. after cessation of exothermic reaction, gave 50.6% 1-methyl-5-chloroimidazole, b9 84°, b10 87°, n22D 1.5120 (picrate m. 167-8°), unreacted amide, and 1-methyl-4,5-dichloroimidazole, m. 58.5-59° (picrate m. 130.5-1.5°; HCl salt m. 161-3°; nitrate m. 122°; sulfate m. 83-5°). Similar reaction of 11.6 g. (CONHMe)2 with 91.6 g. PCl5 and 250 ml. POCl3 in 0.5 hr. at 40-50°, then 1.5 hrs. at 100°, gave a low yield of 1-methyl-2,4,5-trichloroimidazole, m. 75.5-6° (petr. ether), 1-methyl-4,5-dichloroimidazole, isolated as the picrate, and 1-methyl-5-chloroimidazole. Heating 104 g. PBr5 with 14 g. (CONHMe)2 2.1 hrs. on a steam bath gave 19.6% 1-methyl-4,5-dibromoimidazole, m. 79-80° (picrate m. 149.5-50.5°), and 1-methyl-5-bromoimidazole, isolated as the picrate, m. 190-1°. Nitration of the mixed crude mono- and dibromo derivatives with mixed acid 2 hrs. at 100° gave 1-methyl-4-nitro-5-bromoimidazole, m. 180-1°. Heating (CONHMe)2 with PBr5 in POCl3 in 1 hr. at 60-70° and 2 hrs. at reflux gave 1-methyl-2,4,5-tribromoimidazole, m. 93-4°, 1-methyl-4,5-dibromoimidazole, and 1-methyl-5-bromoimidazole, isolated as the picrate.
Zhurnal Obshchei Khimii published new progress about Group 15 element halides, phosphorus halides. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem