Electric Literature of 17325-26-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17325-26-7 as follows.
A mixture of l ,3-dibromo-5-iodo-2-methoxybenzcnc (C) (Chae, J.; Buchwald, S. L. J. Org. Chem. 2004, 69, 3336-3339) ( 1.6 g, 4.1 mmol), methyl 4-imidazolecarboxylate (0.56 g, 4.4 mmol), cesium carbonate (1.31 g, 4.02 mmol) and 4A molecular sieves (0.88 g) in anhydrous DMF (20 tnL) was stirred under nitrogen for 15 min. Copper(II) trifluoromcthanesulfonate (50 mg, 0.14 mmol) was added and the reaction was stirred at 1 10 0C for 12 h. After cooling, the mixture was filtered and the filtrate was evaporated. The residue was treated with water and extracted with ethyl acetate. The organic extract was dried (MgSO4) and evaporated. The residue was purified by flash chromatography to give methyl l-(3,5-dibromo-4-methoxyphenyI)-l H-imidazole-4-carboxylate (D) (0.21 g, 13%). 1H NMR delta (ppm)(DMSO-d6): 3.83 (3 H, s), 3.87 (3 H, s), 8.24 (2 H, s), 8.47 (1 H, d, J = 1.38 Hz), 8.62 ( 1 H, d, J = 1.39 Hz).
According to the analysis of related databases, 17325-26-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INSTITUTE FOR ONEWORLD HEALTH; JONES, Graham Peter; DOYLE, Kevin James; WO2010/33626; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem