The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. HPLC of Formula: 10111-08-7.
Li, Baicun;Zhu, Feifeng;He, Fengming;Huang, Qingqing;Liu, Xiaoguang;Wu, Tong;Zhao, Taige;Qiu, Yingkun;Wu, Zhen;Xue, Yuhua;Fang, Meijuan research published 《 Synthesis and biological evaluations of N’-substituted methylene-4-(quinoline-4-amino)benzoylhydrazides as potential anti-hepatoma agents》, the research content is summarized as follows. In the effort to develop novel quinoline derivatives for the treatment of liver cancer, a series of N’-substituted methylene-4-(quinoline-4-amino)benzoyl hydrazides I (R = n-Pr, 2,6-(MeO)2C6H3, 1H-benzo[d]imidazole-2-yl, etc.) was synthesized and evaluated for their biol. activities as anticancer agents. Compounds I [R = 3,4-dimethoxyphenyl (II), 2,5-dihydroxyphenyl (III)] were found to be the most potent antiproliferative agents against HepG2 cell line with an IC50 value of 12.6 ± 0.1μM and 27.3 ± 1.7μM, resp. Compound II also exhibited potent cytotoxicity against SMMC-7721 and Huh7 cells with IC50 values of 9.6 ± 0.7μM and 6.3 ± 0.2μM, resp. Inspiringly, both II and III exhibited lower cytotoxic property in normal cells than hepatic carcinoma cells. Compounds II and III could down-regulate mRNA level of c-Myc and expression level of c-Myc. Meanwhile, they decreased expression level of anti-apoptotic protein Bcl-2 and increased expression levels of pro-apoptotic protein Bax and cleaved PARP with reference to tubulin. So various assays including cell colony formation, cell cycle distribution, as well as cell apoptosis and migration were performed to understand their antitumor role. It was confirmed that II and III inhibited the growth of HepG2 cells due to their anti-survival effect, induction of cell cycle arrest and cell apoptosis, and inhibition of cell migration. These results demonstrated that II might be a potential lead compound to develop anticancer agents for the treatment of hepatocellular carcinoma.
HPLC of Formula: 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem