On February 15, 2020, Wang, Yixuan; Zhou, Rui; Quan, Yanni; Chen, Shumin; Shi, Xingpeng; Li, Yanping; Cen, Shan published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was Design, synthesis, and evaluation of novel 4-amino-2-(4-benzylpiperazin-1-yl)methylbenzonitrile compounds as Zika inhibitors. And the article contained the following:
The prevalence of Zika virus (ZIKV) has become widespread in recent years. ZIKV infection is associated with severe congenital CNS malformations in both newborns and adults. However, neither vaccines nor therapeutics are available to control ZIKV infection until now. The authors started by hit screening the authors’ inhouse small mol. library, then designed, synthesized, and evaluated a new class of 1,4-bibenzyl-substituted piperazine derivatives for their cytopathic effect (CPE) protection effect in a ZIKV-infected Vero E6 cellular assay. A preliminary structure-activity relation study identified five novel 4-amino-2-(4-benzylpiperazin-1-yl)methylbenzonitrile analogs with obvious CPE reduction effects against ZIKV at micromolar concentrations Moreover, 2-((4-(2-chlorobenzyl)piperazin-1-yl)methyl)-4-((2(dimethylamino)ethyl)(methyl)amino)benzonitrile exerted a significant antiviral effect on both Zika RNA replication and virus protein expression in a dose-dependent manner at low micromolar concentrations This study demonstrated the potential of a novel 4-amino-2-(4-benzylpiperazin-1-yl)methylbenzonitrile scaffold for the development of anti-ZIKV candidates. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole
The Article related to aminobenzylpiperazinylmethylbenzonitrile preparation zika inhibitor, 4-amino-2-(4-benzylpiperazin-1-yl)methylbenzonitrile, antiviral, cytopathic effect, structure-activity relationship, synthesis, zika virus inhibitors and other aspects.Safety of N-(3-Aminopropyl)-imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem